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18 October, Tuesday, Day 1

10:30 - 15:00  

Session 1
Early career scientist workshop: Data presentation best practices

Chair: Uschi Symmons

10:30 - 11:30  Esther Schnapp: Publishing policies and Initiatives at EMBO press
11:30 - 12:30  Helena Jambor: How not to lie with (biomedical) charts
12:30 – 13:00  Break
13:00 – 15:00 Being a data detective: Helena Jambor: Take a sad plot and make it better - Better figures in the biological sciences
12:00 – 15:30   Registration
15:15 – 15:30  Conference Opening
15:30 – 18:15 Session 2
Epigenetics and development

Chair: Petra Hajkova

15:30 – 16:00  Deborah Bourc’his: Epigenetic determinants of germline specification and protection
16:00 – 16:15  Emmanuel Cazottes: Rapid evolution of non-coding regulators of X-inactivation across primates
16:15 – 16:30  Ariella Weinberg-Shukron: Balanced gene dosage control rather than parental origin underpins genomic imprinting
16:30 – 17:00  Coffee break
17:00 – 17:30 Juanma Vaquerizas: Gene regulation in human spermatogenesis 
17:30 – 17:45  Tomasz Jurkowski: Pronounced sequence specificity of the TET enzyme catalytic domain guides its cellular function
17:45 – 18:15  Jop Kind: The chromatin landscape during early embryo development at single-cell resolution
18:30 – 19:30 Session 3
Keynote Lecture

Chair: Petra Hajkova

18:30 – 19:30   Marisa Bartolomei: Epigenetic regulation of imprinted gene clusters
20:00 –  Welcome dinner
ELTE Lágymányosi Campus, Globe Hall

19 October, Wednesday, Day 2

08:30 – 09:30   Breakfast with the invited speakers
(in speakers’ hotel, maximum 3 students / speaker, registration for the programme is needed in advance
09:00 – 10:00  Registration
10:00 – 11:00 Session 4
Epigenetics and transcription

Chair: Tibor Pankotai 

10:00 – 10:30  László Tora: Two related coactivator complexes, SAGA and ATAC, control embryonic stem cell self-renewal through two different acetyltransferase-independent mechanisms
10:30 – 10:45  Gábor Pápai: SAGA saga or, how TBP is deposited on DNA
10:45 – 11:00  Nabieh Ayoub: Transcriptional regulation at DNA double-strand break sites: A spotlight on Lysine Crotonylation
11:00 - 11:30   Coffee Break
11:30 – 12:00  Yitzhak Reizel: FoxA pioneer factors and TET proteins establish a stable epigenetic signature in hepatocytes
12:00 – 12:15  Jannat Ijaz: Epigenetic and transcriptomic alterations caused by shattered chromosomes
12:15 – 12:30  Yoav Voichek: Controlling transcription from within transcribed regions in plants
12:30 – 13:00  Dirk Schübeler: Beyond motif: guiding sites of transcription factor binding by DNA modifications
13:00 - 14:30   Lunch break
14:30 - 17:00   Poster session I.
16:30 - 17:00   Coffee break
17:00 - 19:30 Session 5
Epigenetics and differentiation

Chair: Tamás Arányi

17:00 – 17:30  Marc Bühler: Genetic alterations precede epigenetic gene silencing 
17:30 – 17:45  Melinda Bence: Drosophila piwi protein utilizes molecular mimicry of Sumo to recruit SU(VAR)2-10 to the site of transposon repression
17:45 – 18:00  Suzan Stelloo: Deciphering lineage specification during early embryogenesis using multi-layered proteomics
18:00 – 18:30  Wolf Reik: Single cell multi-omics landscape of development and ageing
18:30 – 18:45 Raffaele Teperino: Parental genetics and epigenetic programming of offspring phenotypes
18:45 – 19:00  Christopher Douse: Layered epigenetic control of transcribed repetitive elements in human brain development
19:00 – 19:30  Sara Annika Wickström: Regulation of stem cell fate by nuclear mechanotransduction
20:00 - Beer session / Meet the lecturers
Cactus Juice Gastro Pub, 1061 Budapest, Jókai tér 5.

20 October, Thursday, Day 3

08:30 – 09:30   Breakfast with the invited speakers (in speakers’ hotel, maximum 3 students / speaker, registration for the programme is needed in advance) 
10:00 – 13:00 Session 6
Epigenetics and physiology

Chair: Lóránt Székvölgyi

10:00 – 10:30  J. Andrew Pospisilik: Epigenetic underpinnings of metabolic disease heterogeneity
10:30 – 10:45  Ilaria Panzeri: Developmental Plasticity as a Predisposing Factor for Tumorigenesis
10:45 – 11:00  Iván P. Uray: Winner of HBS Epigenetics Section Award
Pharmacologic targeting of ARID1A for the non-estrogenic modulation of IGF-1 signaling 
11:00 – 11:30  Coffee Break
11:30 – 12:00  Richárd Bártfai: Epigenetically-regulation of RNA-binding proteins underlies dormancy of relapsing malaria parasites
12:00 - 12:15 Javier Redondo-Muñoz: Functional and mechanical response of epigenetic changes in leukemia cells
12:15 – 12:45 Amos Tanay: Competition and compensation in the epigenetic dynamics of embryonic multifurcation
12:45 - 14:30   Lunch break
14:30 - 17:00   Poster session II.
16:30 - 17:00   Coffee break
17:00 - 19:00 Session 7
Genome architecture

Chair: J. Andrew Pospisilik

17:00 - 17:15 Mutay Aslan: Introducing FEBS activities and programmes
17:15 – 17:45  Lóránt Székvölgyi: Unravelling the genetic architecture of R-loops and chromatin loops
17:45 – 18:15  Giacomo Cavalli: Epigenetic regulation of 3D genome architecture in cell differentiation and development
18:15 – 18:30  László Imre: Epigenetic modulation based on the fundamental role of the C-terminal tail of H2A.Z in determining nucleosome stability, accessibility of DNA in chromatin and nuclear architecture 
18:30 – 19:00  Bas van Steensel: Using random scrambling to decode sequence determinants of nuclear organisation
19:30 - Gala dinner

21 October, Friday, Day 4

09:30 – 13:00 Session 8
Epigenetics and inheritance

Chair: László Tora

09:30 – 10:00  Celia P. Martinez-Jimenez: Effect of ageing on cellular variability and transcriptional dynamics 
10:00 – 10:15  Dick Zijlmans: Integrated multi-omics reveal polycomb repressive complex 2 restricts human trophoblast induction
10:15 – 10:30  Ioannis Kafetzopoulos: Reiterative de novo methylation maintains methylation levels in somatic cells
10:30 – 11:00  Coffee Break
11:00 – 11:30  Ferenc Mueller: Epigenomic organisation and mammalian conservation of cis-regulatory landscape during zebrafish development
11:30 - 11:45   Jose Perez-Mojica: Continuous transcriptome analysis of single embryos reveals novel early transcriptional programs in Drosophila melanogaster
11:45 – 12:00  Kristeli Eleftheriou: Dynamic changes in chromatin configurations in late oogenesis impact the epigenome of the early embryo
12:00 – 12:30 Petra Hajkova: Stability, turnover and erasure of epigenetic information in vivo
12:30 - 13:00   Prizes and concluding remarks
13:00 - 14:30 Farewell snacks

Posters list

Each poster might be mounted during the whole Conference. The recommended poster size is a standing A/0 (84 cm x 119 cm) as the size of the poster board is 90 cm at width and 120 cm at height. Posters left on the boards after the removal deadline will be removed by the organisers.

October 18, from 12:00
Removal: October 21, till 13:00

Technical instructions:

Posters should be prepared for standard STANDING (PORTRAIT) A/0 size (84 x 119 cm – 1 sqm). PLEASE DO NOT PRINT A LANDSCAPE POSTER!
The organisers provide pins to mount your poster to the board at the conference venue and they will be at your disposal if you need help.

P-01 Fatima Al-Ali
Investigating functional consequences of Mcts2 during Embryonic Development
P-02 Tamás Arányi
IMPROVE-RRBS tool Ignores MsPI site and sequencing Read 3’ end OVErlap in RRBS methylation calling
P-03 Marie-Thérèse Bammert
Fueling aberrant cell populations – Metabolic dysregulation drives the progression of pulmonary fibrosis
P-04 Damir Baranasic
Dynamics and locus organisation of enhancers regulating key factors in early zebrafish development
P-05 Ivona Beceheli
The association between cord blood DNA methylation of serotonin-regulating genes and body fat-related characteristics in newborns
P-06 Angéla Békési
Conditions of drug induced enzymatic DNA cytosine deamination and genomic uracil profiles.
P-07 Krisztián Bene
The roles of the transcriptional repressor BACH1 in regulating the differentiation of macrophages
P-08 Jahnavi Bhaskaran
Characterisation of molecular mechanisms of healthy spermatogenesis in humans
P-09 Dóra Bojcsuk
Locus-specific genomic rearrangement of the transcriptional repressor BACH1 upon heme treatment supports transcription
P-10 Thomas Boutet
Unravelling the „inflammatory-chromatin“ epigenetic code using Drosophila genetics
P-11 Aimée Rodica Chis
P-12 Zeina Esmandar
Epigenomic changes upon expression of the transposase-derived SETMAR histone methylase in the human genome
P-13 Norbert Gődér
Examination of 3D genome conformation related to R-loops
P-14 Karolina Gronkowska
Paclitaxel treatment induces BRG1-dependent chromatin remodelling at the promoters of lysosome-localized ABC transporters and confers multidrug resistance
P-15 Eliza Guti
Metformin-induced changes in transcriptomic profile of MCF-7 hormone receptor positive breast carcinoma cell line
P-16 Renáta Hamar
Uncovering the complexity of zebrafish (Danio rerio) snoRNAome
P-17 Emma Hands
The Role of Methylation in the Formation of Pathological R-loops
P-18 Eszter Holub
Altered cell responses induced by two thymidylate synthase inhibitory drugs
P-19 Elizabeth Ing-Simmons
Single-nucleus multiomic analysis of gene regulation in human spermatogenesis
P-20 Sham Jdeed
ARID1A mediates the anti-proliferative effects of bexarotene and carvedilol in normal and transformed breast cells
P-21 Alexandra Kalmár
Genome-wide expression profiling in colorectal cancer focusing on lncRNAs in the adenoma-carcinoma transition
P-22 Kyu-Tae Kim
Exploring the impact of clonal mosaicism in the blood system on cardiac inflammation
P-23 Lilla Kókity
P-24 YuHao Liu
Deciphering The Functions of The Lateral Modifications during Early Developmental Process
P-26 Barbara Kinga Molnár
Analyzing the methylation pattern of cell-free DNA for monitoring the chemotherapy response of colorectal cancer patients
P-27 Iraia Muñoa Hoyos
Chronic morphine treatment prevents the X-chromosome inactivation (XCI)
P-28 Dalma Müller
Integrated dataset of methylome data of colorectal normal, adenoma and adenocarcinoma tissues enables ranking of methylation changes in distinct gene-associated regions
P-29 Gergely Nagy
Dissecting the cistromes determining bone marrow-derived macrophages
P-30 Zsófia Brigitta Nagy
Folic acid combined chemotherapy has an immediate effect on c1-methionin cycle and consequential dna methylation in liquid biopsy samples of colorectal cancer patients
P-31 Subirán Nerea
SMCHD1 is a key regulator of epigenetic cellular memory induced by morphine
P-32 Henri Niskanen
Hijacking of transcriptional condensates by endogenous retroviruses
P-33 Ainize Odriozola
Morphine leads to a global hipometylation via active and pasive demetilation mechanisms in mESCs
P-34 Gabrielle Oxley
Exploring the effects of drug exposure on the developing epigenome using in vitro models
P-35 Gábor Papp
Correlation between uracilation and transcriptional activities in drug treated colon cancer cells
P-36 Máté Posta
Whole genome transcriptomic changes in the placenta suggests epigenetic origins of recurrent pregnancy loss
P-37 Aurél Prósz
Biologically informed deep learning for explainable epigenetic clocks
P-38 Mirabela Romanescu
Therapy induced microRNA modifications in Parkinson’s disease
P-40 Hussein Sabit
Paclitaxel-loaded casein nanoparticles induces apoptosis in breast cancer cells via MAPK pathway
P-41 Hussein Sabit
CRISPR/Cas9-mediated activation of CDH1 suppresses metastasis of breast cancer in rats
P-42 Iris Šalamon Arčan
H3K14ac is decreased through genome in Slovenian male suicide completers
P-43 Kristine Salmina
Amoeboid transition in polyploid breast cancer cells induced after genotoxic treatment is essential for clonogenic resistance
P-44 Federica Sarno
Integrated biological and chemical epigenetic-targeting platform to improve cancer therapy
P-45 Aimee Chis, (Ovidiu Sirbu)
Altered circulating hsa-miR-195-5p level predicts Covid-19 severity in hospitalized patients
P-46 Vaidotas Stankevicius
DNMT1 specific covalent tracing of DNA methylation in mouse embryonic cells
P-47 Krisztina Szigeti
Global DNA hypomethylation could be linked to decreased methyl-donor content in colorectal cancer progression
P-48 Pia Todtenhaupt
Mesenchymal stromal cells as a tool to unravel the epigenetic mechanism underlying the developmental origins of disease
P-49 Dániel Tóth
Generation and characterization of hepatocyte-specific DNA methyltransferase (Dnmt) 3a and Dnmt3b double knockout mice.
P-50 Kayla Townsley
Convergent impact of schizophrenia risk genes
P-51 Sára Zsigrai
Epigenetic reprogramming of colorectal cancer cell lines by S-adenosylmethionine treatment